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"In conclusion, spinal manipulation is based on questionable pathological concepts and therefore lacks biological plausibility. Its risks may be considerable and its benefits have not been convincingly demonstrated in rigorous trials. What follows is sobering: the benefits of spinal manipulation do not seem worth the potential risks." Edzard Ernst, Expert Review of Neurotherapeutics, Vol. 7, No. 11, Pages 1451-1452 (November 2007) Full text available via this link.